This is a list of characters who were antagonists in the Lethal Weapon Series.
Bold stands for major antagonists.
- Jack Joshua: McAllister's second-in-command, who hunts down Michael Hunsaker.
Arjen Rudd: A minister of diplomatic communications and consul of South Africa.
- Pieter Vorstedt: Rudd's head of security,
- Hans: Rudd's henchman, who responsible for exposing the krugerrands by mistake to the police.
- Hatchett: Travis' loyal henchman, who prepares the firearms ready to be shipped to the black market.
- Tyrone: Travis' number one buyer, who leads a street gangsters and deals the ammunition.
- Darryl Smithers: Tyrone's henchman.
Uncle Benny Chan: A Crime boss for the Triads, in charge of smuggling illegal immigrants from China into the United States.
- Wah Sing Ku: A Highest ranked Triad negotiator, trying to get his brother and the Four Fathers out of prison.
- Chinese General: An official, who runs a prison in China, where he's holding the Four Fathers captive.