This is a list of characters who were antagonists in the Lethal Weapon Series.
Bold stands for major antagonists.
- Jack Joshua: McAllister's second-in-command, who hunts down Michael Hunsaker.
Arjen Rudd: A xenophobic minister of diplomatic communications and consul of South Africa who leads the group of diplomats in the krugerrand drug shipments.
- Pieter Vorstedt: Rudd's head of security,
- Hans: Rudd's henchman, who responsible for exposing the krugerrands by mistake to the police.
- Hatchett: Travis' loyal henchman, who prepares the firearms ready to be shipped to the black market.
- Tyrone: Travis' number one buyer, who leads a street gangsters and make deals with the ammunition.
- Darryl Smithers: Tyrone's henchman.
Uncle Benny Chan: The Crime boss of the Triads in charge of smuggling illegal immigrants from China into the United States.
- Wah Sing Ku: A highest ranked Triad negotiator, who leads the group of Triads in the human trafficking and counterfeiting rings while trying to get his brother and the Four Fathers out of prison.
- Chinese General: A corrupt military official, who runs a prison in China where he's holding the Four Fathers captive.